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Consistent with this, expression levels of the long noncoding RNA, maternally expressed 3 ( MEG3 ) and glucose transporter 2 ( SLC2A2 ), both of which contribute to insulin synthesis and secretion (4346), increased in a step-wise fashion from the -1 to -4 subclusters (Figure 3D)

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The dose of PYY-based compounds was escalated at day 4 from 100 nmol kg 1 to 500 nmol kg 1