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According to current study findings, the guideline from ADA 2023 has designated SGLT-2i and GLP-1 RAs as first-line drugs for T2DM patients with established ASCVD or high cardiovascular risk, and metformin is no longer recommended as first-line therapy for T2DM patients with high cardiovascular risk due to its neutral HF benefits

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If your primary electrolyte source has been food rather than supplementation, reduced intake will amplify the keto-induced losses

Zeng T, Li J, Xie L, Dong Z, Chen Q, Huang S, Xie S, Lai Y, Li J, Yan W, Wang Y, Xie Z, Hu C, Zhang J, Kuang S, Song Y, Gao L, Lv Z (2023) Nrf2 regulates iron-dependent hippocampal synapses and functional connectivity damage in depression

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PLoS ONE 10 , (2015)