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New tissue cannot survive without blood supply

Agreeing with our previous results (22), deletion of hepatocyte Dpp4 led to sustained reductions in plasma and hepatic DPP4 activities, with little change in circulating DPP4 protein levels (Figure 3D)

Solution: Reduce volume, not frequency

Weight reduction, cardiovascular protection, and durable glycemic improvement significantly improve patient outcomes

If semaglutide does not produce the desired results, transitioning to tirzepatide through the same platform is straightforward

That's the gap these platforms exist to close - and in a category where many patients previously faced months-long waits for in-person weight management appointments, the difference is real