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In addition to nausea and vomiting, the most common adverse reactions of exenatide long-acting preparations also have a strong immunogenic reaction at the injection site, which is mainly caused by the rejection of polylactic acid-glycolic acid copolymer

Rotating injection sites can help minimize these issues

The FDA has even warned about potential dosing errors with compounded semaglutide injections, with some people having ended up in the hospital after accidental overdoses