tirzepatide phase 3 trial 80 weeks weight change The numbers from Lilly's retatrutide dropped this week and I haven't been able to stop thinking about them. Not only as a doctor but as a long-term GLP-1 user Seven Clinical Trials on Obesity/Weight

A liver-specific knockout mouse exhibited some postnatal growth reduction, but not as severe as with global IGF knockout (Baker et al., 2013)

Drucker commented: GLP1 [drugs] have given us so many wonderful results, but tackling these very challenging brain disorders has been disappointing There was a hope that we would see some benefit, and we didnt. From the Alzheimers Drug Discovery Foundation (ADDF), Howard Fillit, MD, emphasized that even negative trials move the field forward, pointing to the need to target the broader pathobiology of Alzheimers and to consider preventive or combination approaches informed by biomarker profiles

Drucker hinted at early promising results for patients with metabolic liver disease and noted ongoing studies exploring GLP-1's effects on Alzheimer's disease, with results expected soon

Eating three smaller meals plus two snacks throughout the day prevents the deep energy valleys that come with long fasting gaps

If needed, gently swirl the vial, never shake it

Since the price of tirzepatide increases as the maintenance dose rises, there may be local pressure to retain patients on the 5 mg dose