This interaction shields the modified peptide from DPP-4 degradation and slows clearance, extending its circulation time
Renee Rayburg, PSGs vice president of specialty clinical consulting, told Fierce Healthcare in an email that the drugs have not been on the market long enough to provide any historical data
Possible reasons include Type 1 diabetes diagnosis, advanced Type 2 diabetes with severely depleted beta cells, contraindication to GLP-1 drugs (thyroid cancer history, pancreatitis history), insurance or cost barriers, prior GLP-1 intolerance, or very high blood sugar requiring immediate insulin coverage
The European Society of Cardiology (ESC) and Heart Failure Association (HFA) Long-Term Registry, a multinational cohort of 9,428 outpatients with HF compared outcomes between patients with and without DM
Lauby-Secretan B, et al
Participants using metformin experienced improved post-meal glucose control relative to placebo