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This barrier, called the intestinal epithelial barrier, is crucial for maintaining a healthy gut and preventing conditions like leaky gut syndrome (intestinal permeability)

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The discovery that GHK-Cu binds directly to SIRT1 (Li et al., 2025) has generated particular interest, as SIRT1 is a central regulator of cellular longevity and stress resistance

This allows clearer attribution of effects and side effects

10.1016/j.brainres.2014.05.048 51 FineJ

These biochemical alterations could provide a direct measure of disease onset or severity, for example