Additional structural modifications included (i) substitution with aminoisobutyric acid at position 2 to increase resistance to DPP-4-mediated cleavage and inactivation, (ii) the addition of a C-terminal extension with 9 amino acids from exendin-4 to enhance structural stability, and (iii) acylation with a C16:0 fatty acid or PEGylation with 40 kDA PEG to extend in vivo activity, thus enabling daily or weekly administration, respectively [69]
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Summary of the GLP-1 Companion Products Market Market Snapshot In 2025, the global GLP-1 companion products market was valued at approximately USD 4.7 billion
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A significant reduction in the fear of self-injection from baseline to the end of the study was also reported [238]
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