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doi: 10.3390/md21070372 370 HartungNMFischerJOstermannAIWillenbergIRundKMSchebbNHet al
Participants started regaining small amounts of weight almost immediately, a pattern that continued for months if no new habits replaced the medications effects
Protocols are typically 36 months in duration, with reassessment of labs and body composition at regular intervals
Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue
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