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FIGURE 6 12 Concluding remarks and future research In summary, metabolic dysfunction in T2DM affects insulin receptor signaling, inhibiting the PI3K-Akt cascade and enhancing GSK3 hyperactivity, NAD + depletion, and Sirt1/Sirt3 inactivation

Reducing insulin resistance through GLP-1 therapy can partially address these androgenic effects, which is part of why GLP-1 medications have attracted interest in the PCOS community

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Diabetes Obes Metab (2018) 20(9):212130