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Acknowledgements This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541) and financial contributions from Harvard University and its affiliated academic healthcare centers

The glutathione concentration was monitored throughout fermentation to understand the impact of YAN on glutathione consumption

Heterozygous -syn knockout mice received the same chronic hypoxia-inducing treatment

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Engineered bacterial bioreactor for tumor therapy via Fenton-like reaction with localized H2O2 generation

Subcutaneous Injections Often considered for achieving more targeted and systemic effects, subcutaneous injections deliver GHK-Cu directly into the body, allowing for higher bioavailability and more predictable concentrations