Conservative approaches use separate injections
Curr Diab Rep 19 , 138 (2019)
Both have been FDA cleared for their safety and effectiveness
0.22 m) immediately prior to use Aliquot and store reconstituted solutions at 20 C (or lower) to minimise degradation Avoid repeated freezethaw cycles Due to reported low intrinsic stability in vitro, prepare fresh working solutions when possible Specifications Summary Precautions & Notes Experimental behaviour of DSIP is dependent on concentration, exposure duration, and model system Buffer composition, pH, and enzymatic activity may influence peptide stability Due to reported rapid degradation in some in vitro systems, appropriate controls are recommended Literature reports describe heterogeneous and sometimes contradictory findings across models Intended strictly for laboratory research use
This may be explained by the prolonged residence time of PBD-SLN-ISG, which led to a more sustained release profile
This is not a reason to dismiss the compound it is a reason to be honest about what we know and dont know