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Alcoholic myopathy: pathophysiologic mechanisms and clinical Implications

Billah M, Islam R, Khatun H et al (2013) Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves

The first step is mediated by -glutamylcysteine synthetase (GCLC), which catalyzes the -amide bond between the -carboxyl group of glutamate and the amino group of cysteine to form -glutamyl-cysteine (-Glu-Cys)

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C.SarikidiA.et al (2022)

However, if the ATP-depleting futile 5-oxoproline cycle becomes activated, this may also contribute to the hepatic and renal ATP and energy depletion