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Weight Loss : Semaglutide leads to more significant weight loss, often 15-20% of body weight, while berberine promotes modest but steady fat loss, around 5-10 pounds over time

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Neurol Clin 31(1):241268

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It has been shown to promote the healing of ulcers, protect the stomach lining from damage, and reduce inflammation in the gut

If you're in the first two groups: the most important next step is a conversation with your prescribing provider - specifically about a DXA baseline, about whether you're hitting protein targets on a suppressed appetite, and about whether a formal musculoskeletal protection plan makes sense to layer in