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Cobley J, et al

doi: 10.3390/biomedicines10112696

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

Reprod Biomed Online

Retatrutide is now being studied as a triple-receptor medication that may shape the future of obesity medicine, but it remains investigational and should not be obtained from unverified online sellers