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Breakout Clusters: Acne flares occurring within 48-72 hours of treatment due to a disrupted skin barrier 4
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
When NAD+ is preserved, your body can: Use energy more efficiently Support cellular repair and mitochondrial function Burn fat more effectively Regulate inflammation and metabolism with less strain NNMT is a major drain on NAD+, particularly in cells that are already under strain
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