all use must occur within a formally supervised clinical trial, following trial-specific protocols
However, dose adjustment or discontinuation may be appropriate if: hair loss is severe and psychologically devastating despite interventions, you cannot maintain adequate nutrition, youre experiencing multiple severe side effects beyond hair loss, or weight is dropping more than 3 pounds weekly despite dose optimization
The theory is that smaller, more frequent doses maintain receptor stimulation at a level that avoids heavy desensitization while preserving beneficial effects
A licensed healthcare provider will review your health history and goals to determine whether Wegovy may be a safe and suitable option for you
Vitamin B12 deficiency is particularly relevant in patients also taking metformin, which can reduce B12 absorption over time
Sulphonylureas (e.g., gliclazide) and thiazolidinediones (e.g., pioglitazone) are older oral agents still used in certain situations, though they are less commonly prescribed due to side effect profiles, including weight gain and hypoglycaemia risk
