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Administration of the DPP-4 inhibitor, PKF275-055 (3 mg/kg/day), or linagliptin in STZ-induced diabetic rats inhibited macrophage infiltration, inflammatory molecules, and NF- B activity in the glomeruli [105] and significantly reduced glomerular leukocyte infiltration [106]

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Stopping GLP-1 therapy typically results in reversal of therapeutic effects, including deterioration in blood glucose control and weight regain within weeks to months

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