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Group differences in baseline demographics and clinical characteristics of participants between the SCAN and effector groups were statistically assessed using two-tailed independent t -tests or Fishers exact tests, as appropriate (Supplementary Table 5)

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The seminal studies of glycemic control have shown that metabolic memory or legacy effect of early control can prevent or delay the development of diabetic autonomic neuropathy and other complications [10, 11, 13, 144]