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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

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The bile acid receptor Fxr is a modulator of intestinal innate immunity

In psoriasis, DPP4 contributes to the inflammatory process by influencing the function and migration of key immune cells like T cells and dendritic cells, as well as modulating cytokines and chemokines, thereby exacerbating skin inflammation

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45,74 In summary, expanding practical guidance for the management of GI adverse effects is critical to ensuring treatment continuity and maximizing clinical benefit