The experimental drug Apabetalone (RVX-208) in clinical treatment for prediabetes inhibits BET proteins and prevents them from binding to acetylated histones, which reduces the expression of genes involved in lipid metabolism, inflammation, and plaque formation in arteries (19)
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These medications: Increase satiety Reduce appetite Slow digestion However, these treatments require injections, medical supervision, and ongoing use
It was the first hormone-mimicking drug to be approved to treat type 2 diabetes
[DOI] [PMC free article] [PubMed] [Google Scholar] 714.Kishimoto-Urata M., Urata S., Fujimoto C., Yamasoba T
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