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The presence of ulcerative lesions appears to be related to a greater probability of glucocorticoid resistance and greater severity of diarrhea (133)

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The cardiovascular protective effects of GLP-1RA involve multiple molecular mechanisms and signaling pathways

84,85 When the intestinal barrier is compromised, pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) are recognized by dendritic cells and macrophages through Toll-like receptors (TLRs), activating NF-B and MAPK signaling pathways

Overall, we revealed that a high-affinity oxylipin-sensing OR plays key roles in metabolism