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We further explained that, over the last several Shared Savings Program application cycles for ACOs entering a new agreement period, about 2 percent of ACO applicants on average were denied participation in the program due to the ACOs having fewer than 5,000 assigned beneficiaries in BY1, BY2, or both, while still having more than 5,000 assigned beneficiaries in BY3 and meeting all other program eligibility requirements (90 FR 32666)

Activation of these receptor complexes engages G-protein signaling, increasing intracellular cAMP

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Marangoni, R

PMID 21030672

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