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Yoritaka A, Hattori N, Uchida K, Tanaka M, Stadtman ER, Mizuno Y

Human plasma samples were analyzed using both NMR spectroscopy and LCMS/MS for -HB and AcAc quantification, while acetone was measured by GCMS

Long-term use is common, especially when taken in clinically studied doses

N-terminal acetylation, the Nle 4 substitution (methionine replaced by norleucine, oxidation-resistant), the D-Phe 7 substitution (stereochemical inversion resistant to proteolysis) and lactam cyclization are the four pharmacochemical innovations that transform alpha-MSH's 2-5 minute half-life into a multi-hour half-life