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For instance, greater abdominal fat is associated with increased risk for cardiovascular disease and type 2 diabetes

Its role is also being investigated for Alzheimers disease and dementia, cardiovascular and peripheral artery disease, insulin resistance and diabetes, infertility, osteoarthritis, athletic performance enhancement, and weight loss

As a Category 2 substance it is not covered by FDA's enforcement-discretion policy [17]

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This occurs by increasing ROS production and decreasing neuronal and glial cell viability [92]