The treatment significantly ameliorated cognitive and memory impairment, improved glutamate and gamma-aminobutyric acid levels, preserved glutathione levels, and antioxidant enzyme activity
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Starting from one of the first studies on this topic, it has been demonstrated that missense mutations on codon 132 in IDH1 gene are present in different tumor types diverse than glioblastoma multiforme or gliomas, including prostate carcinomas [43], opening the way to the investigation of the role of 2-HG also in this tumor type
Combination effect of flavonoids attenuates lung cancer cell proliferation by inhibiting the STAT3 and FAK signaling pathway
However, further work is required to standardise synthesis approaches, define safety profiles, and validate efficacy in physiologically relevant models to support future clinical translation
