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Gastroparesis: This condition, in which the stomach takes too long to empty its contents, can lead to severe discomfort and health complications

Cell surface expression Cell surface expression was detected using a cell surface ELISA to detect a double c-Myc epitope label incorporated with the N-terminal region of the GLP-1R constructs

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We were able to show that the circulating form of DPP4 (sDPP4), which lacks the cytoplasmic domain and the transmembrane region, is cleaved off the membrane of human adipocytes and smooth muscle cells in a process called shedding by the involvement of matrix metalloproteases (MMPs) ( Within the TMD, it could be shown that proline residues play an important role for the translocation of membrane-anchored proteins, such as DPP4

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Leveraging this distribution, insulin can be administered to the brain via the olfactory and trigeminal nerve pathways