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La combinacin de inyeccin de DES IGF-1 inmediatamente antes de entrenar el msculo objetivo intenta capitalizar la sinergia entre estas dos seales de activacin: el DES IGF-1 inicia la activacin de clulas satlite mediada por el IGF-1R, y la carga mecnica posterior del entrenamiento amplifica y sostiene esa activacin, impulsando una mayor proliferacin y diferenciacin de clulas satlite que cualquiera de las dos seales por s sola

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