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While eligibility for tirzepatide is determined based on individual factors, there are general guidelines under which it will be prescribed to nondiabetic patients

Appetite rebounds, often exceeding pre-treatment levels in the short term

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Beyond quantitative preservation, maintaining skeletal muscle function, including strength and metabolic capacity, remains a critical therapeutic goal in ensuring long-term health outcomes

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That might mean focusing more on lifestyle changes, switching medications, or considering bariatric surgery. For some patients, surgical options such as sleeve gastrectomy may be appropriate, particularly if they want a more durable intervention