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Indeed, natural cationic peptides were firstly isolated from different organisms and identified as AMPs before their anticancer potential started to be investigated [59]

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5 Therapeutic resistance and AKR1C3 AKR1C3, overexpressed in various cancer tissues, has been associated with disease progression and poor prognosis, playing a pivotal role in resistance to multiple cancer treatment modalities, including radiation, chemotherapy drugs, and steroid drugs