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The FDA approval process requires extensive Phase I-III clinical trials demonstrating safety, efficacy, pharmacokinetics, and quality manufacturing standards

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Chen J, Xu S, Zhou W, Wu L, Wang L, Li W

The five qualifying conditions The five qualifying conditions for the NHS pathway under NICE TA1026 are 4 : Type 2 diabetes High blood pressure (hypertension) Cardiovascular disease (previous heart attack, stroke, angina, or coronary procedure) High cholesterol or dyslipidaemia Obstructive sleep apnoea For the private route, the Mounjaro and Wegovy product licences accept any one of these, plus prediabetes (an HbA1c blood-sugar reading between 42 and 47 mmol/mol) 1,2

Management is multidisciplinary and focuses on symptom control and improving quality of life: Exercise programmes : Tailored aerobic and strengthening exercises are first-line interventions

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