However, it is crucial to note that berberine is not a licensed medicine in the UK and is instead sold as a food supplement, meaning it has not undergone the rigorous pharmaceutical evaluation required for medicinal products
Patients with significant medical history (kidney disease, severe asthma, certain medications) should disclose them in the pre-procedure assessment
Prices may vary based on location
According to the recently reported results of a phase 2 trial in patients with gastrointestinal stromal tumors, linsitinib achieved no objective responses in these patients, although the rate of 9-month clinical benefit, progression-free survival, and overall survival at 9 months was 40%, 52% and 80%, respectively [162]
Nature 383 , 447450 (1996)
Limit intake to 200 to 400 mg daily (roughly two to four cups of coffee)