Key drivers of this decline include age-associated upregulation of CD38 the primary NAD+-consuming enzyme in mammalian tissues and increased PARP activity driven by accumulating DNA damage
haemolyticus is consistent with the notion that the ability to acquire diverse haem sources provides an adaptive advantage in pathogenic isolates (Qu et al., 2010
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10.1101/gad.279737.116 [DOI] [PMC free article] [PubMed] [Google Scholar] Gasparri A