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Reductive stress occurs when there is an excess of antioxidant power in the cells, which can actually interfere with normal cellular signalling

Furthermore, patients with HF, composite cardiovascular events, and clinically significant portal hypertension events before the index period were excluded

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Additionally, patients taking medications that cause weight gain (certain antipsychotics, antidepressants, or corticosteroids) may experience slower weight loss

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Market analysts have echoed this enthusiasm, with pipeline assessments highlighting tirzepatide's success as validation of the dual-agonist approach and positioning triple agonists as the next wave [18, 19]