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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

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Raval NR, Johansen A, Donovan LL, Ros NF, Ozenne B, Hansen HD, et al

Genes associated with inflammation were upregulated while genes involved in tissue remodeling and repair were markedly downregulated

J Obstet Gynecol Neonatal Nurs

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