In addition to suPAR, galectin-3, a key regulator of fibrosis and inflammation, is strongly associated with cardiac remodeling, hepatic fibrosis, and kidney disease progression, with elevated levels linked to higher mortality in heart failure (HF) and liver fibrosis (8)
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Osteoporosis is a skeletal disease characterized by low bone mass and microarchitectural deterioration of the bone tissue, with a consequent increase in bone fragility that increases the risk for fracture
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Originally discovered as a gut hormone secreted by the endocrine L-cells in the small intestine and colon, GLP-1 acts on multiple organ systems to regulate nutrient ingestion and blood glucose 7,8,9,10,11,12,13,14
The prevalence and incidence of IBD are rising worldwide, placing a significant burden on healthcare systems and social resources ( A promising explanation could be represented by the complex interplay between inflammation and metabolism, which is still largely unknown in the field of IBD management