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Notably, as suggested in an animal model of neuroinflammation induced by ischemic stroke damage known to increase the prevalence of M1 microglia in the brain, pre-treatment with melatonin upregulated the expression of TREM2 while downregulating that of proinflammatory genes in microglia (e.g., inducible nitric oxide synthase) [101], suggesting that melatonin may polarize microglia towards its M2 phenotype

BPC-157 | Side Effects and Complications When comparing the safety and side effects of TB-500 vs BPC-157, it is important to note that only TB-500 has been extensively clinically studied

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