fda warning letters compounded semaglutide tirzepatide 2025 New project announcement: HHS‑OIG is taking a closer look at FDA's oversight of GLP‑1 drugs. Although shortages ended in 2025, some facilities may still be producing these drugs at scale. Our US FDA warns online vendors

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This review seeks to provide further clinical context both to assist in the creation of future high-quality evidence and guidelines as well as to assist providers in making informed, evidence-driven decision to enhance outcomes and minimize risks in the perioperative period for this patient population

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Although experiments with transgenic mice have shown that in the absence of phase I oxidative pathways and therefore NAPQI formation, hepato-toxicity does not occur, the precise pathway lead-ing to liver damage is still unclear (Gibson et al ., 1996)