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In the context of cuproptosis, autophagy may regulate the process by removing copper-induced aggregation of proteins or damaged mitochondria (173)

In addition to downregulating the expression of Cytochrome P450 2E1 (CYP2E1), a critical enzyme that catalyzes ethanol oxidation to generate ROS, C3G can also change the morphology of mitochondria and enhance the expression of mitochondrial autophagy-related genes, thereby protecting mitochondria from damage

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To that end we used a strain of NKG2D KO ( Klrk1 / ) mice that have been previously described 26

Lactate levels in renal cortical homogenate are slightly higher in SHR than WKY 55