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Notably, a large insertion (D504-Q599) into the C-terminal basic leucine zipper (bZIP) domain of Met4 in the Kluyveromyces clade and Saccharomyces species abolished its ability to directly bind DNA 28

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This influences OXPHOS function and leads to increased ROS production (31)

Migraine Early studies suggest that people who regularly have migraine may also have low levels of l-arginine

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The deduced amino acid sequence of peroxisomal APX has a high degree of identity with cytosolic APX, but it has a C-terminal amino acid extension containing a single, putative membranespanning region (Mullen et al., 1999)