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Reviews typically cant control for confounders (diet changes, exercise, stimulant intake, sleep, stress, or other supplements), and negative experiences are often underreported

It remains an investigational compound

Vaccination rates were historically low because of poor public health management and the 2018 deaths of two babies whose vaccines were incorrectly prepared, prompting fears that the MMR immunization was unsafe before the nature of the error was discovered

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The addition of HCG to this protocol remains investigational in conventional medicine, but some specialized weight loss clinics report enhanced fat loss and preserved lean muscle when both agents are used together under medical supervision