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In line with this, a study using postmortem brain tissues from PD patients and controls, as well as monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), found over-expression of ICAM-1 in the substantia nigra of patients with PD and in the MPTP monkeys [156]
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18 Cytokines can provoke OS by activating macrophages, which have a key function in removing the pathogens via the generation of ROS
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