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Poster Session II - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P1017 - ESOC25-519 VAGOTOMY AND RISK OF STROKE COMPARED WITH MATCHED GENERAL POPULATION: A POPULATION-BASED COHORT STUDY Oscar Rosenkrantz 1 , Pter Szentkti 1 , Nils Skajaa 2 , Dvid Nagy 1 , Erzsbet Horvth-Puh 1 , Holly Elser 1,3,4 , Cecilia Hvitfeldt Fuglsang 1 , Henrik Toft Srensen 1 1 Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark, 2 Novo Nordisk A/S, Sborg, Denmark, 3 Department of Neurology, University of Pennsylvania, Philadelphia, United States, 4 Center for Population Health Sciences, Stanford University, Palo Alto, United States Background and Aims: Vagotomy, used to treat refractory peptic ulcers decades ago, has been associated with reduced risk of selected neurological diseases, possibly by disrupting axonal transport of microbial organisms or misfolded proteins via the vagus nerve to the brain