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Mice were euthanized by cervical dislocation, and the tumor were removed for weighing and volume measurement at endpoint

Administered under the supervision of Dr

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When the MC1R is fully functional, it produces brown-black pigments inside melanocyte cells

We then added the PKA pathway inhibitor H89 to mimic the effect of A2ARi in compromising activated T cell survival (Supplemental Figure 6, G and H) while upregulating GSH metabolic genes ( gclc , gclm , and gpx4 ) (Supplemental Figure 6I)

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