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The nuclear factor erythroid 2-related factor 2 ( NFE2L2 or NRF2) transcription factor is constitutively activated in many cancers and promotes a specific gene expression program involved in cellular detoxification, redox buffering, and metabolic rewiring (Cancer Genome Atlas Research, 2012

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When we try to look at the effects on glucose and insulin and doing what we call dose response experiments, where we increase the dose to see how much you can actually obtain with this, then we also found, as we increased the doses, people would start to get sick