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3.1 Agonist-stimulated signaling at the WT GIP receptor In the global population, glutamine (E) is the most common residue reported at position 354 of the GIP receptor and was therefore considered the reference sequence, or wildtype (WT) form of the GIP receptor for this research ( 2 , to activate the WT human GIP receptor was compared for five signaling pathways, cAMP, IP 1 , AKT, ERK1/2, and CREB