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In the liver, where glycogen stores are highest, under stress conditions, a substantial part of formed G6P is dephosphorylated by glucose-6-phosphate phosphatase and released into the bloodstream to provide energy for muscle and brain tissue (Van Schaftingen and Gerin, 2002)

In particular, MUFA-containing ethers were enriched (Fig

While many of the key regulators of this pathway remain largely unknown, recent studies have identified glutathione peroxidases, particularly glutathione peroxidase 4 (GPX4), as antioxidant enzymes that can prevent lipid peroxidation using reduced glutathione (GSH) as a co-factor 9,10

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Under normal physiological conditions, NRF2 acts as a master regulator of antioxidant response, becoming activated during oxidative stress to upregulate antioxidant gene expression [9]