Long-term safety will also be critical if IN chelation therapy is to be considered for chronic use
The study found that high glucose-induced loss of PCBP1 activates the HIF-1/HO-1 pathway, leading to intracellular iron homeostasis imbalance and increased ferrous ion levels, while also exacerbating lipid peroxidation and ferroptosis
Without long-term human studies, its safety profile remains largely unknown
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This review focuses on how GLP-1RAs impact lipid-related outcomes
Ultimately, this work aims to provide a comprehensive overview of carnitine supplementation as a therapeutic approach in the management of hemodialysis patients, highlighting both its potential advantages and the challenges that remain in its widespread implementation