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Less Common but Serious Concerns Gallbladder disease Pancreatitis (rare) Dehydration from persistent nausea At Florida Endocrinology and Diabetes Center, careful titration and monitoring minimize these risks

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Nausea typically peaks 24 to 48 hours after your first dose and usually resolves within 5 to 7 days as your body adapts

They may check your B6 levels, adjust the formulation, or investigate other causes

The following common side effects were reported in more than 10% of people using naltrexone for addiction treatment in studies: Insomnia Anxiety or nervousness Stomach pain Nausea or vomiting Low energy Pain in joints or muscles Headache Similar side effects can occur when naltrexone is taken with bupropion

Jin, L., Alesi, G