Predictors of continuous positive airway pressure adherence in patients with obstructive sleep apnea
Multiple studies have demonstrated that GLP-1RAs significantly reduce the thickness or volume of EAT: once-weekly GLP-1RAs (semaglutide, dulaglutide) significantly decrease ultrasound-measured EAT thickness in a dose-dependent manner (162)
Additionally, the secondary bile acids 3-oxoLCA and isoLCA function as TGR5 agonists that suppress the differentiation of Th17 cells in vitro through two mechanisms: (1) directly inhibiting the expression of RORt, and (2) promoting the polarization of M2 macrophages, which indirectly inhibits the development of Th17 cells (119)
The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response [seeWarnings and Precautions (5.14),Use in Specific Populations (8.5), andClinical Pharmacology (12.3)]
According to animal studies, berberine could bring some unintended negative consequences for intestinal microbes
But it does require a different approach